(This page was last updated on January 8, 2006)

The Salvia divinorum Research and Information Center
is created and maintained by
Daniel Siebert


The Salvia divinorum Observer provides timely updates on Salvia divinorum-related news and events. You are encouraged to subscribe to this free newsletter.

Science news

Quantification of the plant-derived hallucinogen Salvinorin A in conventional and non-conventional biological fluids
by gas chromatography/mass spectrometry after Salvia divinorum smoking.
by Pichini S, Abanades S, Farre M, Pellegrini M, Marchei E, Pacifici R, Torre RD, and Zuccaro P.

Synthesis and in vitro pharmacological evaluation of salvinorin A analogues modified at C(2).
by Beguin C, Richards MR, Wang Y, Chen Y, Liu-Chen LY, Ma Z, Lee DY, Carlezon WA Jr, and Cohen BM.

Identification of the molecular mechanisms by which the diterpenoid salvinorin A binds to kappa-opioid receptors.
by Yan F, Mosier PD, Westkaemper RB, Stewart J, Zjawiony JK, Vortherms TA, Sheffler DJ, and Bryan L. Roth BL.

Studies Toward the Pharmacophore of Salvinorin A, a Potent Kappa Opioid Receptor Agonist.
This paper describes investigations into the structure-activity relationships of salvinorin A.

Localization of salvinorin A and related compounds in glandular trichomes of the psychoactive sage, Salvia divinorum.
This paper identifies peltate glandular trichomes as structures that secrete salvinorins.

Salvinorin A, an active component of the hallucinogenic sage Salvia divinorum, is a highly efficacious
kappa opioid receptor agonist: structural and functional considerations.
Experimental data is presented that shows salvinorin A is an extraordinarily potent kappa-opioid receptor agonist.

Salvinorin A: A potent naturally occurring nonnitrogenous k opioid selective agonist.
This paper reports the landmark discovery that salvinorin A activates kappa opioid receptors.

Antidepressant Effects of the Herb Salvia divinorum: A Case Report.
Describes some aspects of the theraputic potential of Salvia divinorum.

Acute physiologic and chronic histologic changes in rats and mice exposed to the unique hallucinogen salvinorin A.
Experiments in rodents indicate that salvinorin A is extraordinarily low in toxicity.

Legal status

Information about Salvia's legal status, and pending legislation that might affect it, is available at: http://sagewisdom.org/legalstatus.html.

Recent and forthcoming publications

Divine Sage. Daniel Siebert's big book of Salvia divinorum. A work in progress. Publication planned for late 2005.

The Salvia divinorum FAQ has recently been updated.

The Salvia divinorum User's Guide has recently been updated.


The Sage Wisdom Salvia Shop. Top quality Salvia divinorum leaves, rare clones, extracts, books, and related products can now be purchased directly from Daniel Siebert. The proceeds of all sales directly support important and much needed Salvia divinorum related research, scientific expeditions, and educational publications, such as those found on my Salvia divinorum web site: http://sagewisdom.org.

Sage Goddess Emerald Essence. This is a specially formulated extract of Salvia divinorum designed for sublingual absorption. This product has taken years to develop. It is the most effective form of Salvia divinorum available for oral ingestion. Many people have been requesting such a product and now it is finally available.